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There seems to be agreement that a data-centric rather than a document-centric approach to interoperability is the way forward. But no one really knows what is going to happen when the technological capabilities of open application programming interfaces (APIs) and FHIR (Fast Healthcare Interoperability Resources) profiles run up against the business models of EHR vendors and health systems. Who will want to share patient data with startups developing apps that may threaten to make obsolete part of their EHR system?